Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications
Copyright policy )Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications
Male germ cell development depends on multiple biological events that combine epigenetic reprogramming, cell cycle regulation, and cell migration in a spatio-temporal manner. Sertoli cells are a crucial component of the spermatogonial stem cell niche and provide essential growth factors and chemokines to developing germ cells. This review focuses mainly on the activation of master regulators of the niche in Sertoli cells and their targets, as well as on novel molecular mechanisms underlying the regulation of growth and differentiation factors such as GDNF and retinoic acid by NOTCH signaling and other pathways.
- University of California System United States
- University of Southern California United States
Male, Sertoli Cells, Cell Differentiation, germ cell, differentiation, Cell Communication, self-renewal, RC648-665, Sertoli cell, Diseases of the endocrine glands. Clinical endocrinology, Spermatogonia, Endocrinology, growth factors, Humans, Stem Cell Niche
Male, Sertoli Cells, Cell Differentiation, germ cell, differentiation, Cell Communication, self-renewal, RC648-665, Sertoli cell, Diseases of the endocrine glands. Clinical endocrinology, Spermatogonia, Endocrinology, growth factors, Humans, Stem Cell Niche
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