Genetic Polymorphisms inFAS(CD95) andFAS Ligand(CD178) Promoters and Risk of Tobacco-related Oral Carcinoma: Gene–Gene Interactions in High-risk Indians
Copyright policy )Genetic Polymorphisms inFAS(CD95) andFAS Ligand(CD178) Promoters and Risk of Tobacco-related Oral Carcinoma: Gene–Gene Interactions in High-risk Indians
We assessed the association of functional single nucleotide polymorphisms (SNP) in FAS -1377, -670 and FAS ligand (FASL) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP. In logistic regression analysis FAS -1377 GA genotype appeared to marginally increase the risk while FASL -844 TC genotype appeared as low risk factor. The combined genotypes FAS -1377 GA or AA and FASL -844 TT (p <0.03), and FAS -670 AG or GG and FASL -844 TT (p <0.007) appeared to double the risk. FAS and FASL gene-gene and gene-environment interactions seems to modulate susceptibility/resistance to tobacco-related oral cancer in Indians.
Adult, Male, Fas Ligand Protein, Genotype, Smoking, Middle Aged, Polymorphism, Single Nucleotide, Asian People, Gene Frequency, Risk Factors, Case-Control Studies, Humans, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Mouth Neoplasms, fas Receptor, Aged
Adult, Male, Fas Ligand Protein, Genotype, Smoking, Middle Aged, Polymorphism, Single Nucleotide, Asian People, Gene Frequency, Risk Factors, Case-Control Studies, Humans, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Mouth Neoplasms, fas Receptor, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).12 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!