Association of Polymorphisms in Dickopff ( DKK) Gene Towards Modulating Risk for Lung Cancer in North Indians
Copyright policy )Association of Polymorphisms in Dickopff ( DKK) Gene Towards Modulating Risk for Lung Cancer in North Indians
To investigate the association between the genetic variants of DKK4 (rs2073664), DKK3 (rs2291599, rs3206824 and rs7391689) and DKK2 (rs447372, rs419558 and rs17037102) and lung cancer predisposition in north Indians.A total of 600 subjects were genotyped using PCR restriction fragment length polymorphism technique. Association analysis was carried out using logistic regression approach.DKK3 rs7396187 showed a protective effect (p = 0.01). Subjects with heterozygous genotype of DKK2 rs17037102 and rs419558 showed an increased risk. The variant genotype of the genotypic combination, DKK3 rs3206824 and DKK2 rs419558 showed a twofold increased risk (p = 0.008). Lung cancer risk increased four-times in subjects with variant genotype of all the three DKK2 variants.DKK2 is certainly playing a crucial role in modulating cancer susceptibility.
Male, Risk, Lung Neoplasms, Genotype, India, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Tumor Burden, Gene Frequency, Haplotypes, Risk Factors, Case-Control Studies, Humans, Intercellular Signaling Peptides and Proteins, Female, Genetic Predisposition to Disease, Neoplasm Metastasis, Alleles, Genetic Association Studies, Neoplasm Staging
Male, Risk, Lung Neoplasms, Genotype, India, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Tumor Burden, Gene Frequency, Haplotypes, Risk Factors, Case-Control Studies, Humans, Intercellular Signaling Peptides and Proteins, Female, Genetic Predisposition to Disease, Neoplasm Metastasis, Alleles, Genetic Association Studies, Neoplasm Staging
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