C to U RNA editing mediated by APOBEC 1 requires RNA ‐binding protein RBM 47
Copyright policy )C to U RNA editing mediated by APOBEC 1 requires RNA ‐binding protein RBM 47
Cytidine (C) to Uridine (U) RNA editing is a post-transcriptional modification that is accomplished by the deaminase APOBEC1 and its partnership with the RNA-binding protein A1CF. We identify and characterise here a novel RNA-binding protein, RBM47, that interacts with APOBEC1 and A1CF and is expressed in tissues where C to U RNA editing occurs. RBM47 can substitute for A1CF and is necessary and sufficient for APOBEC1-mediated editing in vitro. Editing is further impaired in Rbm47-deficient mutant mice. These findings suggest that RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing.
- University of Sydney Australia
- Children's Medical Research Institute Australia
Cell Nucleus, APOBEC-1 Deaminase, Gene Expression, RNA-Binding Proteins, Mice, Transgenic, Cytidine, Protein Transport, Cytidine Deaminase, Animals, Humans, RNA Editing, RNA, Messenger, Caco-2 Cells, Uridine
Cell Nucleus, APOBEC-1 Deaminase, Gene Expression, RNA-Binding Proteins, Mice, Transgenic, Cytidine, Protein Transport, Cytidine Deaminase, Animals, Humans, RNA Editing, RNA, Messenger, Caco-2 Cells, Uridine
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