A Novel Function forFoxm1in Interkinetic Nuclear Migration in the Developing Telencephalon and Anxiety-Related Behavior
Copyright policy )A Novel Function forFoxm1in Interkinetic Nuclear Migration in the Developing Telencephalon and Anxiety-Related Behavior
Interkinetic nuclear migration (INM) is a key feature of cortical neurogenesis. INM functions to maximize the output of the neuroepithelium, and more importantly, balance the self-renewal and differentiation of the progenitors. Although INM has been reported to be highly correlated with the cell cycle, little is known about the effects of cell cycle regulators on INM. In this study, by crossingFoxm1fl/flmice withEmx1-Cre line, we report that a conditional disruption of forkhead transcription factor M1 (Foxm1) in dorsal telencephalon results in abnormal cell cycle progression, leading to impaired INM through the downregulation ofCyclin b1andCdc25b. The impairment of INM disturbs the synchronization of apical progenitors (APs) and promotes the transition from APs to basal progenitors (BPs) in a cell-autonomous fashion. Moreover, ablation ofFoxm1causes anxiety-related behaviors in adulthood. Thus, this study provides evidence of linkages among the cell cycle regulatorFoxm1, INM, and adult behavior.
- Southeast University China (People's Republic of)
Telencephalon, Behavior, Animal, Neurogenesis, Forkhead Box Protein M1, Forkhead Transcription Factors, Anxiety, Real-Time Polymerase Chain Reaction, Immunohistochemistry, Mice, Mutant Strains, Kinetics, Mice, Cell Movement, Animals, In Situ Hybridization, Cell Proliferation
Telencephalon, Behavior, Animal, Neurogenesis, Forkhead Box Protein M1, Forkhead Transcription Factors, Anxiety, Real-Time Polymerase Chain Reaction, Immunohistochemistry, Mice, Mutant Strains, Kinetics, Mice, Cell Movement, Animals, In Situ Hybridization, Cell Proliferation
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