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Apoptosis in peripheral neuroblastic tumors. Immunohistochemical expression of bcl-2 and p53 is related to DNA fragmentation.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2007 Spain English Publisher:Murcia: F. HernándezJournal:Histology and histopathology, volume 22 (issn: 1699-5848,

Authors: Mejía, C.; Navarro, S.; Llombart-Bosch, A.;

doi: 10.14670/hh-22.1365

pmid: 17701916

handle: 10201/28480

Apoptosis in peripheral neuroblastic tumors. Immunohistochemical expression of bcl-2 and p53 is related to DNA fragmentation.

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Abstract

We examined 111 cases of neuroblastoma (NB), searching for how NB relates to apoptotic control and other prognostic factors. Immunohistochemistry using avidin-biotin-peroxidase was carried out for bcl-2 and p53 proteins. Apoptosis was analyzed by in situ detection of chromosomal breakdown. DNA ladders were detected by electrophoresis and amplification of MYCN was carried out by PCR and Southern blot. Statistical analyses were performed with Pearson's chi2 and Kruskal-Wallis tests and Cox's regression. We found expression of bcl-2 protein mainly in cases of neuroblastoma without differentiation and in stages 3 and 4. Expression of p53 protein showed a correlation with bcl-2 and the apoptotic phenomenon; apoptosis was found mainly in favorable cases. Multivariate analysis showed bcl-2 protein expression to be the most independent risk factor. The study of apoptosis could be important for the design of therapies to treat neuroblastoma.

Country

Spain

Related Organizations

University of Murcia
Spain
National Autonomous University of Mexico
Mexico

Keywords

616.8 - Neurología. Neuropatología. Sistema nervioso, Biotin, Apoptosis, DNA Fragmentation, Avidin, Genes, p53, Prognosis, Immunohistochemistry, Biochemical apoptosis, Gene Expression Regulation, Neoplastic, Neuroblastoma, Peroxidases, Proto-Oncogene Proteins c-bcl-2, Risk Factors, Multivariate Analysis, Humans, Tumor Suppressor Protein p53

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