Analysis of Netrin 1 receptors during inner ear development
Copyright policy )Analysis of Netrin 1 receptors during inner ear development
Netrin 1 plays key roles in axon guidance and neuronal migration during central nervous system (CNS) development. Outside the CNS, Netrin 1 has been shown to be involved in epithelial morphogenesis of various organs. We have shown that Netrin 1 is essential for inner ear semicircular duct formation, but the involvement of Netrin 1 receptors in this process has remained unknown. Netrin 1 receptors include members of the Deleted in colorectal cancer (Dcc), Unc5-homologue and integrin families. Here we have analysed the expression of these receptor genes during inner ear development and verified the inner ear phenotypes of several receptor mutant mice. Special interest was directed to receptors that could cooperate with Netrin 1 during semicircular duct formation. We show that Neogenin (Neo1), Unc5c as well as integrin b1 (Itgb1) are expressed in periotic mesenchyme, while Dcc, Unc5b, Unc5c, Itga3, Itga6 and Itgb1 are expressed in different parts of the otic epithelium. In spite of the broad and strong expression of several receptors in ear region, none of the analysed receptor mutant embryos showed any defects in inner ear development.
- University of Helsinki Finland
- Biotechnology Institute United States
Mice, Knockout, Integrins, Tumor Suppressor Proteins, Gene Expression Regulation, Developmental, Receptors, Cell Surface, Netrin-1, DCC Receptor, Mice, Protein Subunits, Ear, Inner, Animals, Nerve Growth Factors, Netrin Receptors, In Situ Hybridization
Mice, Knockout, Integrins, Tumor Suppressor Proteins, Gene Expression Regulation, Developmental, Receptors, Cell Surface, Netrin-1, DCC Receptor, Mice, Protein Subunits, Ear, Inner, Animals, Nerve Growth Factors, Netrin Receptors, In Situ Hybridization
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