CDO, an Hh-Coreceptor, Mediates Lung Cancer Cell Proliferation and Tumorigenicity through Hedgehog Signaling
Copyright policy )CDO, an Hh-Coreceptor, Mediates Lung Cancer Cell Proliferation and Tumorigenicity through Hedgehog Signaling
Hedgehog (Hh) signaling plays essential roles in various developmental processes, and its aberrant regulation results in genetic disorders or malignancies in various tissues. Hyperactivation of Hh signaling is associated with lung cancer development, and there have been extensive efforts to investigate how to control Hh signaling pathway and regulate cancer cell proliferation. In this study we investigated a role of CDO, an Hh co-receptor, in non-small cell lung cancer (NSCLC). Inhibition of Hh signaling by SANT-1 or siCDO in lung cancer cells reduced proliferation and tumorigenicity, along with the decrease in the expression of the Hh components. Histological analysis with NSCLC mouse tissue demonstrated that CDO was expressed in advanced grade of the cancer, and precisely co-localized with GLI1. These data suggest that CDO is required for proliferation and survival of lung cancer cells via Hh signaling.
- Samsung (South Korea) Korea (Republic of)
- Sungkyunkwan University Korea (Republic of)
- Sungkyul University Korea (Republic of)
Lung Neoplasms, Carcinogenesis, Cell Survival, Science, Mice, Nude, Apoptosis, Zinc Finger Protein GLI1, Cell Line, Tumor, Animals, Humans, Hedgehog Proteins, Cell Proliferation, Neoplasm Staging, Tumor Suppressor Proteins, Q, R, Medicine, Female, Cell Adhesion Molecules, Neoplasm Transplantation, Research Article, Signal Transduction, Transcription Factors
Lung Neoplasms, Carcinogenesis, Cell Survival, Science, Mice, Nude, Apoptosis, Zinc Finger Protein GLI1, Cell Line, Tumor, Animals, Humans, Hedgehog Proteins, Cell Proliferation, Neoplasm Staging, Tumor Suppressor Proteins, Q, R, Medicine, Female, Cell Adhesion Molecules, Neoplasm Transplantation, Research Article, Signal Transduction, Transcription Factors
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