Population Genomics: Whole-Genome Analysis of Polymorphism and Divergence in Drosophila simulans
Copyright policy )Population Genomics: Whole-Genome Analysis of Polymorphism and Divergence in Drosophila simulans
The population genetic perspective is that the processes shaping genomic variation can be revealed only through simultaneous investigation of sequence polymorphism and divergence within and between closely related species. Here we present a population genetic analysis of Drosophila simulans based on whole-genome shotgun sequencing of multiple inbred lines and comparison of the resulting data to genome assemblies of the closely related species, D. melanogaster and D. yakuba. We discovered previously unknown, large-scale fluctuations of polymorphism and divergence along chromosome arms, and significantly less polymorphism and faster divergence on the X chromosome. We generated a comprehensive list of functional elements in the D. simulans genome influenced by adaptive evolution. Finally, we characterized genomic patterns of base composition for coding and noncoding sequence. These results suggest several new hypotheses regarding the genetic and biological mechanisms controlling polymorphism and divergence across the Drosophila genome, and provide a rich resource for the investigation of adaptive evolution and functional variation in D. simulans.
- University of Wisconsin–Oshkosh United States
- University of Wisconsin–Madison United States
- Duke University United States
- University of California, Berkeley United States
- University of Mary United States
Biomedical and clinical sciences, Genome, Insect, 11 Medical and Health Sciences (for), Medical and Health Sciences, 3105 Genetics (for-2020), Linkage Disequilibrium, Drosophila Proteins (mesh), veterinary and food sciences, Linkage Disequilibrium (mesh), Models, 31 Biological sciences (for-2020), Medicine and Health Sciences, X Chromosome (mesh), Animals (mesh), Drosophila Proteins, Biology (General), Developmental Biology (science-metrix), Genome, Drosophila (mesh), Generic health relevance (hrcs-hc), Chromosome Mapping, Genomics, Biological Sciences, 06 Biological Sciences (for), 07 Agricultural and Veterinary Sciences (for), Molecular (mesh), Drosophila, Biotechnology, Chromosome Mapping (mesh), Research Article, 570, Population (mesh), X Chromosome, Evolution, QH301-705.5, Population, Molecular Sequence Data, 610, Biotechnology (rcdc), 30 Agricultural, 3104 Evolutionary Biology (for-2020), 576, Evolution, Molecular, Molecular Sequence Data (mesh), Genetic, veterinary and food sciences (for-2020), Genetics, Animals, Polymorphism, Genetic Variation (mesh), 1.1 Normal biological development and functioning (hrcs-rac), Evolutionary Biology, Agricultural, 31 Biological Sciences (for-2020), Polymorphism, Genetic, Agricultural and Veterinary Sciences, Models, Genetic, Genetics (rcdc), Human Genome, Molecular, Genetic Variation, Human Genome (rcdc), Genetics, Population, 32 Biomedical and clinical sciences (for-2020), Genomics (mesh), Genetic (mesh), Generic health relevance, Insect, Insect (mesh), Developmental Biology
Biomedical and clinical sciences, Genome, Insect, 11 Medical and Health Sciences (for), Medical and Health Sciences, 3105 Genetics (for-2020), Linkage Disequilibrium, Drosophila Proteins (mesh), veterinary and food sciences, Linkage Disequilibrium (mesh), Models, 31 Biological sciences (for-2020), Medicine and Health Sciences, X Chromosome (mesh), Animals (mesh), Drosophila Proteins, Biology (General), Developmental Biology (science-metrix), Genome, Drosophila (mesh), Generic health relevance (hrcs-hc), Chromosome Mapping, Genomics, Biological Sciences, 06 Biological Sciences (for), 07 Agricultural and Veterinary Sciences (for), Molecular (mesh), Drosophila, Biotechnology, Chromosome Mapping (mesh), Research Article, 570, Population (mesh), X Chromosome, Evolution, QH301-705.5, Population, Molecular Sequence Data, 610, Biotechnology (rcdc), 30 Agricultural, 3104 Evolutionary Biology (for-2020), 576, Evolution, Molecular, Molecular Sequence Data (mesh), Genetic, veterinary and food sciences (for-2020), Genetics, Animals, Polymorphism, Genetic Variation (mesh), 1.1 Normal biological development and functioning (hrcs-rac), Evolutionary Biology, Agricultural, 31 Biological Sciences (for-2020), Polymorphism, Genetic, Agricultural and Veterinary Sciences, Models, Genetic, Genetics (rcdc), Human Genome, Molecular, Genetic Variation, Human Genome (rcdc), Genetics, Population, 32 Biomedical and clinical sciences (for-2020), Genomics (mesh), Genetic (mesh), Generic health relevance, Insect, Insect (mesh), Developmental Biology
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).561 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!