A homolog of Drosophila Notch expressed during mammalian development
Copyright policy )A homolog of Drosophila Notch expressed during mammalian development
ABSTRACT Drosophila Notch and the related Caenorhabditis elegans proteins lin-12 and glp-1 function as mediators of local cell-cell interactions required for cell-fate decisions during invertebrate development. To investigate the possibility that similar proteins play determinative roles during mammalian development, we isolated cDNA clones encoding rat Notch. The deduced amino acid sequence of this protein contains 36 epidermal growth factor (EGF)-like repeats, and is remarkably similar in both its extracellular and cytoplasmic domains to the sequence of Xenopus Xotch and Drosophila Notch. In the developing central nervous system, in situ hybridisation analyses revealed that Notch transcripts were dramatically restricted to the ventricular proliferative zones of embryonic neuroepithelia. Notch was also strongly expressed during development of non-neural tissues, such as hair follicles and tooth buds, whose correct differentiation requires epithelial-mesenchymal interactions. These data support the hypothesis that Notch plays an essential role in mammalian development and pattern formation that closely parallels its role in the development of invertebrates.
- Salk Institute for Biological Studies United States
Brain Chemistry, Embryonic Induction, Mammals, Embryo, Nonmammalian, Receptors, Notch, Molecular Sequence Data, Gene Expression, Membrane Proteins, Nucleic Acid Hybridization, Blotting, Northern, Embryo, Mammalian, Rats, Mice, Insect Hormones, Sequence Homology, Nucleic Acid, Animals, Drosophila Proteins, Drosophila, Amino Acid Sequence, DNA, Circular
Brain Chemistry, Embryonic Induction, Mammals, Embryo, Nonmammalian, Receptors, Notch, Molecular Sequence Data, Gene Expression, Membrane Proteins, Nucleic Acid Hybridization, Blotting, Northern, Embryo, Mammalian, Rats, Mice, Insect Hormones, Sequence Homology, Nucleic Acid, Animals, Drosophila Proteins, Drosophila, Amino Acid Sequence, DNA, Circular
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