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Morphogens, their identification and regulation

descriptionPublicationkeyboard_double_arrow_right Article 15 Feb 2004 English Publisher:The Company of BiologistsJournal:Development, volume 131, pages 703-712 (issn: 0950-1991, eissn: 1477-9129,

Authors: Yuki Takei; Tetsuya Tabata;

doi: 10.1242/dev.01043

pmid: 14757636

Morphogens, their identification and regulation

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Abstract

During the course of development, cells of many tissues differentiate according to the positional information that is set by the concentration gradients of morphogens. Morphogens are signaling molecules that emanate from a restricted region of a tissue and spread away from their source to form a concentration gradient. As the fate of each cell in the field depends on the concentration of the morphogen signal, the gradient prefigures the pattern of development. In this article, we describe how morphogens and their functions have been identified and analyzed, focusing on model systems that have been extensively studied.

Related Organizations

University of Tokyo
Japan

Keywords

Central Nervous System, Chick Embryo, Zebrafish Proteins, Nodal Signaling Ligands, Transforming Growth Factor beta, Morphogenesis, Trans-Activators, Animals, Drosophila Proteins, Wings, Animal, Drosophila, Hedgehog Proteins

79 Research products, page 1 of 8

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	404
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%