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Evolutionary adaptation of the Polycomb repressive complex 2

descriptionPublicationkeyboard_double_arrow_right Article , Conference object , Other literature type 22 Feb 2022 English Publisher:Springer Science and Business Media LLCJournal:Epigenetics & Chromatin, volume 15 (eissn: 1756-8935,

Authors: Sabrina Fischer; Lisa Marie Weber; Robert Liefke;

doi: 10.1186/s13072-022-00439-6

pmid: 35193659

pmc: PMC8864842

Evolutionary adaptation of the Polycomb repressive complex 2

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Abstract

AbstractThe Polycomb repressive complex 2 (PRC2) is an essential chromatin regulatory complex involved in repressing the transcription of diverse developmental genes. PRC2 consists of a core complex; possessing H3K27 methyltransferase activity and various associated factors that are important to modulate its function. During evolution, the composition of PRC2 and the functionality of PRC2 components have changed considerably. Here, we compare the PRC2 complex members of Drosophila and mammals and describe their adaptation to altered biological needs. We also highlight how the PRC2.1 subcomplex has gained multiple novel functions and discuss the implications of these changes for the function of PRC2 in chromatin regulation.

Related Organizations

Philipps University of Marburg
Germany
Universitätsklinikum Gießen und Marburg
Germany
Philipps-University of Marburg
Germany

Keywords

Cell Nucleus, Mammals, Polycomb Repressive Complex 1, Evolution, EPOP, Polycomb Repressive Complex 2, Review, QH426-470, PRC2, PALI1, Chromatin, Polycomb, Genetics, Animals, Drosophila

10 Research products, page 1 of 1

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%