Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas
Copyright policy )Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas
Deregulation of CDK4/6, cyclin D/P16 and retinoblastoma (Rb) are known aberrations in certain malignancies. There has been a recent interest in exploring the combination of letrozole and CDK4/6 inhibitors in recurrent ER+ ovarian cancers.This study aimed to determine the frequency of expression of Rb1, P16 and ER in ovarian epithelial tumors by immunohistochemistry.Co-expression of all 3 markers studied was seen in 10% of high grade serous carcinoma (HGSC) and low grade serous carcinoma (LGSC). Coordinate expression of Rb1+ and ER+ in HGSC and LGSC was seen in 67% of grade 1/2 vs. 44 % of grade three tumors (p < 0.05). The reverse was true with positive P16 staining in 73% of grade three vs. 32% of grade 1/2 tumors (p < 0.001).Coordinate pattern of Rb1+ and ER+ in HGSC and LGSC is 19 and 50%, respectively. Rb1 and P16 show inverse expression pattern according to tumor grade with more frequent Rb1 in low grade vs. more frequent P16 in grade 3 tumors. These data provide a rational basis for clinical trials that aim to target these proteins.
- Vanderbilt University School of Medicine United States
- Sarah Cannon Research Institute United Kingdom
- University of California, San Diego United States
- Vanderbilt University School of Medicine United States
- University of California, San Francisco United States
Ovarian Neoplasms, Research, Estrogen Receptor alpha, Carcinoma, Ovarian Epithelial, Prognosis, Retinoblastoma Protein, Gene Expression Regulation, Neoplastic, Oncology, Obstetrics and Gynaecology, Biomarkers, Tumor, Humans, Female, Neoplasms, Glandular and Epithelial, Cyclin-Dependent Kinase Inhibitor p16, Neoplasm Staging
Ovarian Neoplasms, Research, Estrogen Receptor alpha, Carcinoma, Ovarian Epithelial, Prognosis, Retinoblastoma Protein, Gene Expression Regulation, Neoplastic, Oncology, Obstetrics and Gynaecology, Biomarkers, Tumor, Humans, Female, Neoplasms, Glandular and Epithelial, Cyclin-Dependent Kinase Inhibitor p16, Neoplasm Staging
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