Association of a Notch 3 gene polymorphism with migraine susceptibility
Copyright policy )Association of a Notch 3 gene polymorphism with migraine susceptibility
Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) shares common symptoms with migraine. Most CADASIL causative mutations occur in exons 3 and 4 of the Notch 3 gene. This study investigated the role of C381T (rs 3815188) and G684A (rs 1043994) single nucleotide polymorphisms (SNP) in exons 3 and 4, respectively, of the Notch 3 gene in migraine. Results: The first part of the study, in a population of 275 migraineurs and 275 control individuals, found a significant association between the C381T variant and migraine, specifically in migraine without aura (MO) sufferers. The G684A variant was also found to be significantly associated with migraine, specifically in migraine with aura (MA) sufferers. A follow-up study in 300 migraineurs and 300 control individuals did not show replicated association of the C381T variant with migraineurs. However, the G684A variant was again shown to be significantly associated with migraine, specifically with MA. Conclusion: Further investigation of the G684A variant and the Notch 3 gene is warranted to understand their role in migraine.
- University of Queensland Australia
- Institute of Environmental Science and Research New Zealand
- Griffith University Australia
- Queensland University of Technology Australia
- QIMR Berghofer Medical Research Institute Australia
Genotype, Receptors, Notch, Migraine Disorders, Clinical Sciences, Neurosciences, 610, CADASIL, 600, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Notch 3, Humans, Genetic Predisposition to Disease, 2728 Clinical Neurology, Medical and Health Sciences not elsewhere classified, Receptor, Notch3, Migraine
Genotype, Receptors, Notch, Migraine Disorders, Clinical Sciences, Neurosciences, 610, CADASIL, 600, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Notch 3, Humans, Genetic Predisposition to Disease, 2728 Clinical Neurology, Medical and Health Sciences not elsewhere classified, Receptor, Notch3, Migraine
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