The role of herpesvirus entry mediator as a negative regulator of T cell–mediated responses
Copyright policy )The role of herpesvirus entry mediator as a negative regulator of T cell–mediated responses
Herpesvirus entry mediator (HVEM), a TNF receptor superfamily member, has been previously described as a T cell costimulatory receptor. Surprisingly, HVEM-/- T cells showed enhanced responses to in vitro concanavalin A (ConA) stimulation when compared with WT T cells. Consistent with these findings, HVEM-/- mice exhibited increased morbidity and mortality as compared with WT mice in a model of ConA-mediated T cell-dependent autoimmune hepatitis. HVEM-/- mice produced higher levels of multiple cytokines, which were dependent on the presence of CD4+ T cells. Furthermore, HVEM-/- mice were more susceptible to MOG peptide-induced experimental autoimmune encephalopathy, and they showed increased T cell proliferation and cytokine production in response to antigen-specific challenge. Taken together, our data revealed an unexpected regulatory role of HVEM in T cell-mediated immune responses and autoimmune diseases.
- University of Chicago United States
- Technical University of Munich Germany
- Heinrich Heine University Düsseldorf Germany
- Institute of Medical Microbiology and Hygiene Germany
- University of Duesseldorf Germany
Mice, Knockout, Tumor Necrosis Factor Ligand Superfamily Member 14, Encephalomyelitis, Autoimmune, Experimental, Tumor Necrosis Factor-alpha, T-Lymphocytes, Membrane Proteins, Lymphocyte Activation, Receptors, Tumor Necrosis Factor, Mice, Inbred C57BL, Survival Rate, Mice, Liver, Concanavalin A, Animals, Cytokines, Humans, Receptors, Virus, Disease Susceptibility, Receptors, Tumor Necrosis Factor, Member 14, Spleen
Mice, Knockout, Tumor Necrosis Factor Ligand Superfamily Member 14, Encephalomyelitis, Autoimmune, Experimental, Tumor Necrosis Factor-alpha, T-Lymphocytes, Membrane Proteins, Lymphocyte Activation, Receptors, Tumor Necrosis Factor, Mice, Inbred C57BL, Survival Rate, Mice, Liver, Concanavalin A, Animals, Cytokines, Humans, Receptors, Virus, Disease Susceptibility, Receptors, Tumor Necrosis Factor, Member 14, Spleen
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