The Potential Functional Interaction of Biglycan and WISP-1 in Controlling Differentiation and Proliferation of Osteogenic Cells
Copyright policy )The Potential Functional Interaction of Biglycan and WISP-1 in Controlling Differentiation and Proliferation of Osteogenic Cells
Biglycan (BGN) and WISP-1 are 2 extracellular matrix proteins that bind to each other and colocalize in mineralizing tissue. Here we show that WISP-1 abrogates the repression of proliferation in bone marrow stromal cells induced by BGN. We also demonstrate that WISP-1 and its variant WISP-1va can alleviate the repressed osteogenic differentiation caused by the absence of BGN. These preliminary data suggest that WISP-1 and BGN may functionally interact and control each other’s activity, thus regulating the differentiation and proliferation of osteogenic cells.
- National Institute of Dental and Craniofacial Research United States
- National Institutes of Health United States
- National Institute of Health Pakistan
- University of Salford United Kingdom
Proliferation, Fluorescent Antibody Technique, Bone Marrow Cells, Osteocytes, CCN Intercellular Signaling Proteins, Mice, Osteogenesis, Proto-Oncogene Proteins, Biglycan, Animals, Humans, Cell Proliferation, WISP-1/CCN4, Extracellular Matrix Proteins, Microscopy, Confocal, Intracellular Signaling Peptides and Proteins, Cell Differentiation, Protein Structure, Tertiary, Bromodeoxyuridine, Proteoglycans, WISP-1va, Stromal Cells, Protein Binding
Proliferation, Fluorescent Antibody Technique, Bone Marrow Cells, Osteocytes, CCN Intercellular Signaling Proteins, Mice, Osteogenesis, Proto-Oncogene Proteins, Biglycan, Animals, Humans, Cell Proliferation, WISP-1/CCN4, Extracellular Matrix Proteins, Microscopy, Confocal, Intracellular Signaling Peptides and Proteins, Cell Differentiation, Protein Structure, Tertiary, Bromodeoxyuridine, Proteoglycans, WISP-1va, Stromal Cells, Protein Binding
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