Thrombomodulin Ala455Val Dimorphism Is Not Associated with Pre-Eclampsia in Australian and New Zealand Women
Copyright policy )Thrombomodulin Ala455Val Dimorphism Is Not Associated with Pre-Eclampsia in Australian and New Zealand Women
Thrombomodulin plays an important role in thromboresistance. A common mutation of the gene at amino acid 455 producing valine instead of alanine has been implicated as being a risk factor in myocardial infarction and chronic heart disease. However, its link with pre-eclampsia remains controversial. This report explores the Ala455Val point mutation in 280 women as a predictor of pre-eclampsia with the conclusion that in this regard, the dimorphism is essentially neutral.
- University College Cork Ireland
- Royal Women's Hospital Australia
- University of Melbourne Australia
Polymorphism, Genetic, Base Sequence, Thrombomodulin, Molecular Sequence Data, Australia, DNA, Polymerase Chain Reaction, Cohort Studies, Pre-Eclampsia, Pregnancy, Mutation, Humans, Female, Genetic Predisposition to Disease, Alleles, New Zealand
Polymorphism, Genetic, Base Sequence, Thrombomodulin, Molecular Sequence Data, Australia, DNA, Polymerase Chain Reaction, Cohort Studies, Pre-Eclampsia, Pregnancy, Mutation, Humans, Female, Genetic Predisposition to Disease, Alleles, New Zealand
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