Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11
Copyright policy )Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11
We have characterized a 185-kb contig surrounding a transgene on distal mouse chromosome 11, the insertion of which has caused a recessive phenotype with skeletal malformations. By cDNA selection and sequencing we have found six genes <i>(Lasp1, Rpl23, Mllt6, Pip5k2b, Psmb3, Zfp144)</i>, one truncated gene <i>(Mel13)</i>, and one pseudogene <i>(Rps15-ps)</i> within this region. The murine <i>Mllt6</i> gene is new, it was identified by its high homology (90% identity) with the human homologue MLLT6. <i>Psmb3</i> and <i>Pip5k2b</i> had not yet been assigned to mouse chromosomes. A comparison with the corresponding region on human chromosome 17q12 revealed several small-scale rearrangements during evolutionary divergence within this cluster of densely packed genes.
Gene Rearrangement, Homeodomain Proteins, Iron-Sulfur Proteins, DNA, Complementary, Base Sequence, Genetic Linkage, LIM Domain Proteins, Chromosomes, Mammalian, Collagen Type I, Collagen Type I, alpha 1 Chain, DNA-Binding Proteins, Evolution, Molecular, Cytoskeletal Proteins, Mice, Lac Operon, DNA Transposable Elements, Animals, Humans, Collagen, Adaptor Proteins, Signal Transducing
Gene Rearrangement, Homeodomain Proteins, Iron-Sulfur Proteins, DNA, Complementary, Base Sequence, Genetic Linkage, LIM Domain Proteins, Chromosomes, Mammalian, Collagen Type I, Collagen Type I, alpha 1 Chain, DNA-Binding Proteins, Evolution, Molecular, Cytoskeletal Proteins, Mice, Lac Operon, DNA Transposable Elements, Animals, Humans, Collagen, Adaptor Proteins, Signal Transducing
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