Some Basic Aspects of HLA-G Biology
Copyright policy )Some Basic Aspects of HLA-G Biology
Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.
- Clinica Universidad de Navarra Spain
- University of Ferrara Italy
- University of Navarra Spain
- University of Florence Italy
HLA-G Antigens, Exosomes; Gene Expression Regulation; HLA-G Antigens; Humans; Membrane Proteins; Promoter Regions, Genetic; Protein Isoforms; Protein Multimerization; Protein Structure, Tertiary; Receptors, Immunologic; Solubility; Ubiquitination; Protein Processing, Post-Translational; Immunology and Allergy; Immunology, Bioquímica clínica, Ubiquitination, Membrane Proteins, Expression, Review Article, RC581-607, Exosomes, Human leukocyte antigen-G, Protein Structure, Tertiary, Gene Expression Regulation, Solubility, Humans, Protein Isoforms, Immunologic diseases. Allergy, Protein Multimerization, Receptors, Immunologic, Promoter Regions, Genetic, Biology, Protein Processing, Post-Translational
HLA-G Antigens, Exosomes; Gene Expression Regulation; HLA-G Antigens; Humans; Membrane Proteins; Promoter Regions, Genetic; Protein Isoforms; Protein Multimerization; Protein Structure, Tertiary; Receptors, Immunologic; Solubility; Ubiquitination; Protein Processing, Post-Translational; Immunology and Allergy; Immunology, Bioquímica clínica, Ubiquitination, Membrane Proteins, Expression, Review Article, RC581-607, Exosomes, Human leukocyte antigen-G, Protein Structure, Tertiary, Gene Expression Regulation, Solubility, Humans, Protein Isoforms, Immunologic diseases. Allergy, Protein Multimerization, Receptors, Immunologic, Promoter Regions, Genetic, Biology, Protein Processing, Post-Translational
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