Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension
Copyright policy )Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension
We demonstrate that the modulation of p66Shc signaling impairs cerebral artery myogenic tone in a low renin model of hypertension. This impairment is dependent upon the genetic background, as modulated p66Shc signaling in Sprague-Dawley rats does not impair cerebral artery myogenic tone.
- Medical College of Wisconsin United States
Male, Middle Cerebral Artery, Rats, Inbred Dahl, Src Homology 2 Domain-Containing, Transforming Protein 1, Blood Pressure, Nitric Oxide, Rats, Rats, Sprague-Dawley, Disease Models, Animal, NG-Nitroarginine Methyl Ester, Cerebrovascular Circulation, Hypertension, Renin, Animals, Homeostasis, Female, Rats, Transgenic, Sodium Chloride, Dietary
Male, Middle Cerebral Artery, Rats, Inbred Dahl, Src Homology 2 Domain-Containing, Transforming Protein 1, Blood Pressure, Nitric Oxide, Rats, Rats, Sprague-Dawley, Disease Models, Animal, NG-Nitroarginine Methyl Ester, Cerebrovascular Circulation, Hypertension, Renin, Animals, Homeostasis, Female, Rats, Transgenic, Sodium Chloride, Dietary
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