Structure of an HIV-2 gp120 in Complex with CD4
Copyright policy )Structure of an HIV-2 gp120 in Complex with CD4
ABSTRACT HIV-2 is a nonpandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term nonprogression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30 to 40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0-Å structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence.
- California Institute of Technology United States
- University of California, San Francisco United States
Models, Molecular, 570, Protein Conformation, 610, HIV Envelope Protein gp120, Crystallography, X-Ray, Medical and Health Sciences, Models, Virology, 2.2 Factors relating to the physical environment, Humans, Aetiology, Crystallography, Agricultural and Veterinary Sciences, Molecular, Biological Sciences, Infectious Diseases, Good Health and Well Being, CD4 Antigens, HIV-2, X-Ray, HIV/AIDS, Infection
Models, Molecular, 570, Protein Conformation, 610, HIV Envelope Protein gp120, Crystallography, X-Ray, Medical and Health Sciences, Models, Virology, 2.2 Factors relating to the physical environment, Humans, Aetiology, Crystallography, Agricultural and Veterinary Sciences, Molecular, Biological Sciences, Infectious Diseases, Good Health and Well Being, CD4 Antigens, HIV-2, X-Ray, HIV/AIDS, Infection
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