In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy
Copyright policy ) Nathan P. Wiederhold; Xin Xu; Amy Wang; Laura K. Najvar; Edward P. Garvey; Elizabeth A. Ottinger; Asaf Alimardanov; +9 Authors
Nathan P. Wiederhold; Xin Xu; Amy Wang; Laura K. Najvar; Edward P. Garvey; Elizabeth A. Ottinger; Asaf Alimardanov; Jim Cradock; Mark Behnke; William J. Hoekstra; Stephen R. Brand; Robert J. Schotzinger; Rosie Jaramillo; Marcos Olivo; William R. Kirkpatrick; Thomas F. Patterson;
In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy
VT-1129 is a novel fungal enzyme-specific Cyp51 inhibitor with potent cryptococcal activity. Because of its long half-life (>6 days in mice) and our desire to quickly reach potent efficacy, we evaluated a VT-1129 loading dose-maintenance dose strategy against cryptococcal meningitis.
- South Texas Veterans Health Care System United States
- National Institute of Health Pakistan
- Durham University United Kingdom
- National Institutes of Health United States
- National Center for Advancing Translational Sciences United States
Male, Mice, Inbred ICR, Antifungal Agents, Pyridines, Brain, Tetrazoles, Microbial Sensitivity Tests, Meningitis, Cryptococcal, Mice, Cryptococcus neoformans, Animals
Male, Mice, Inbred ICR, Antifungal Agents, Pyridines, Brain, Tetrazoles, Microbial Sensitivity Tests, Meningitis, Cryptococcal, Mice, Cryptococcus neoformans, Animals
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).22 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 22
Top 10%
Average
Top 10%
bronze
