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Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults

descriptionPublicationkeyboard_double_arrow_right Article 27 Oct 2015 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Signaling, volume 8 (issn: 1945-0877, eissn: 1937-9145,

Authors: Fumi Shishido; Takayuki Kuraishi; Takayuki Kuraishi; Hirotaka Kanoh; Yoshiki Momiuchi; Li Li Tong; Yamato Suda; +1 Authors

doi: 10.1126/scisignal.2005971

pmid: 26508789

Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults

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Abstract

Ubiquitylation and SUMOylation of the adaptor protein dMyd88 are required for Toll-dependent immune responses in Drosophila .

Related Organizations

Tohoku University
Japan
National Presto Industries
United States
Japan Science and Technology Agency
Japan

Keywords

Ubiquitin-Protein Ligases, SUMO-1 Protein, Toll-Like Receptors, Protein Serine-Threonine Kinases, Gram-Positive Bacteria, Drosophila melanogaster, Animals, Drosophila Proteins, RNA, Small Interfering, Gram-Positive Bacterial Infections, Genome-Wide Association Study

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