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EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

descriptionPublicationkeyboard_double_arrow_right Article 27 Jan 2009 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Signaling, volume 2 (issn: 1945-0877, eissn: 1937-9145,

Authors: Daphne A. Haas-Kogan; Qi-Wen Fan; Frank McCormick; William A. Weiss; Zachary A. Knight; David Stokoe; C. David James; +2 Authors

doi: 10.1126/scisignal.2000014

pmid: 19176518

pmc: PMC2793677

EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

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Abstract

Akt is dispensable for signaling between EGFR and mTOR in glioma cells, whereas PKC is critical.

Related Organizations

University of California, San Francisco
United States
University of California System
United States
Howard Hughes Medical Institute
United States
University of California San Francisco Medical Center
United States

Keywords

Brain Neoplasms, TOR Serine-Threonine Kinases, Glioma, Models, Biological, ErbB Receptors, Gene Expression Regulation, Neoplastic, Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Humans, Enzyme Inhibitors, Protein Kinases, Protein Kinase C, Cell Proliferation, Signal Transduction

52 Research products, page 1 of 6

Receptor protein-tyrosine kinase
2017IsRelatedTo
Uncharacterized protein EGFR
2017IsRelatedTo
Protein kinase C
2017IsRelatedTo
Protein kinase C, alpha variant
2017IsRelatedTo
Serine-threonine protein kinase
2017IsRelatedTo
Receptor protein-tyrosine kinase
2017IsRelatedTo
Protein kinase C
2017IsRelatedTo
Epidermal growth factor receptor
2017IsRelatedTo
Receptor protein-tyrosine kinase
2017IsRelatedTo
Epidermal growth factor receptor
2017IsRelatedTo

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	159
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%