Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions
Copyright policy )Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions
Chromosome-capping enzyme complex Telomeres cap and protect the ends of our chromosomes. The telomerase complex helps maintain the telomere DNA repeat sequences. Telomerase consists of an RNA and a number of protein subunits. Jiang et al. used cryo–electron microscopy and x-ray crystallography to determine the structure of the Tetrahymena telomerase complex. The telomerase is made up of three subcomplexes, which include two previously unknown protein subunits in addition to the seven known subunits. The structures also reveal the path of the RNA component in the telomerase catalytic core. Science , this issue p. 10.1126/science.aab4070
- University of California, Santa Barbara United States
- University of California, Berkeley United States
- United States Department of Energy United States
- University of California, Los Angeles United States
- California NanoSystems Institute United States
570, General Science & Technology, Protein Conformation, 1.1 Normal biological development and functioning, Telomere-Binding Proteins, DNA, Single-Stranded, Crystallography, X-Ray, Single-Stranded, Catalytic Domain, Replication Protein A, Genetics, Telomerase, Crystallography, Cryoelectron Microscopy, Telomere Homeostasis, DNA, Biological Sciences, Telomere, Protein Subunits, Physical Sciences, Tetrahymena, X-Ray, RNA, Biochemistry and Cell Biology, Holoenzymes, Protein Binding
570, General Science & Technology, Protein Conformation, 1.1 Normal biological development and functioning, Telomere-Binding Proteins, DNA, Single-Stranded, Crystallography, X-Ray, Single-Stranded, Catalytic Domain, Replication Protein A, Genetics, Telomerase, Crystallography, Cryoelectron Microscopy, Telomere Homeostasis, DNA, Biological Sciences, Telomere, Protein Subunits, Physical Sciences, Tetrahymena, X-Ray, RNA, Biochemistry and Cell Biology, Holoenzymes, Protein Binding
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