Coupling Termination of Transcription to Messenger RNA Maturation in Yeast
Copyright policy )Coupling Termination of Transcription to Messenger RNA Maturation in Yeast
The direct association between messenger RNA (mRNA) 3′-end processing and the termination of transcription was established for the CYC1 gene of Saccharomyces cerevisiae . The mutation of factors involved in the initial cleavage of the primary transcript at the poly(A) site ( RNA14 , RNA15 , and PCF11 ) disrupted transcription termination at the 3′ end of the CYC1 gene. In contrast, the mutation of factors involved in the subsequent polyadenylation step ( PAP1 , FIP1 , and YTH1 ) had little effect. Thus, cleavage factors link transcription termination of RNA polymerase II with pre-mRNA 3′-end processing.
- French National Centre for Scientific Research France
- University of Basel Switzerland
- University of Bordeaux France
- Institut des Sciences Biologiques France
- Institut de Biochimie et Génétique Cellulaires France
mRNA Cleavage and Polyadenylation Factors, Saccharomyces cerevisiae Proteins, Transcription, Genetic, Genes, Fungal, Temperature, Cytochromes c, Nuclear Proteins, RNA-Binding Proteins, Cytochrome c Group, Pancreatitis-Associated Proteins, RNA, Fungal, Saccharomyces cerevisiae, [SDV] Life Sciences [q-bio], Fungal Proteins, Mutation, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, RNA Precursors, RNA Polymerase II, RNA, Messenger, Poly A
mRNA Cleavage and Polyadenylation Factors, Saccharomyces cerevisiae Proteins, Transcription, Genetic, Genes, Fungal, Temperature, Cytochromes c, Nuclear Proteins, RNA-Binding Proteins, Cytochrome c Group, Pancreatitis-Associated Proteins, RNA, Fungal, Saccharomyces cerevisiae, [SDV] Life Sciences [q-bio], Fungal Proteins, Mutation, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, RNA Precursors, RNA Polymerase II, RNA, Messenger, Poly A
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