Three-dimensional structure of recombinant human interferon-gamma
Copyright policy )Three-dimensional structure of recombinant human interferon-gamma
The x-ray crystal structure of recombinant human interferon-gamma has been determined with the use of multiple-isomorphous-replacement techniques. Interferon-gamma, which is dimeric in solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the asymmetric unit. The protein is primarily alpha helical, with six helices in each subunit that comprise approximately 62 percent of the structure; there is no beta sheet. The dimeric structure of human interferon-gamma is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions.
- Alabama Agricultural and Mechanical University United States
- University of Alabama at Birmingham United States
Models, Molecular, Interferon-gamma, Glycosylation, X-Ray Diffraction, Macromolecular Substances, Protein Conformation, Sequence Homology, Nucleic Acid, Molecular Sequence Data, Humans, Amino Acid Sequence, Crystallization, Recombinant Proteins
Models, Molecular, Interferon-gamma, Glycosylation, X-Ray Diffraction, Macromolecular Substances, Protein Conformation, Sequence Homology, Nucleic Acid, Molecular Sequence Data, Humans, Amino Acid Sequence, Crystallization, Recombinant Proteins
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