Influenza A virus uses the aggresome processing machinery for host cell entry
Copyright policy )Influenza A virus uses the aggresome processing machinery for host cell entry
Flu mimics damaged proteins during entry Viruses are master manipulators. The early stages of how flu viruses enter cells are very well understood, but Banerjee et al. describe a new wrinkle (see the Perspective by Rajsbaum and García-Sastre). It seems that the virus carries with it into the cell ubiquitin: a molecule involved in marking proteins for destruction. The virus then exploits host cell machinery involved in recognizing and dealing with damaged proteins to uncoat its own RNA genome, ready to continue its path toward successful infection. Science , this issue p. 473 ; see also p. 427
- University of Basel Switzerland
- ETH Zurich Switzerland
- University of Bristol United Kingdom
- Institute of Molecular Health Sciences Switzerland
- Friedrich Miescher Institute Switzerland
Protein Folding, Protein Structure, 570, Knockout, Inbred C57BL, Virus Replication, Research Support, Histone Deacetylase 6, Membrane Fusion, Microtubules, Histone Deacetylases, Cell Line, N.I.H., Gene Knockout Techniques, Mice, Capsid, Cell Line, Tumor, Influenza, Human, Journal Article, Animals, Humans, Non-U.S. Gov't, Cell Nucleus, Mice, Knockout, Myosin Type II, Tumor, Ubiquitin, Extramural, Dyneins, Dynactin Complex, Virus Internalization, Influenza, Mice, Inbred C57BL, Ribonucleoproteins, Influenza A virus, Host-Pathogen Interactions, RNA Interference, Microtubule-Associated Proteins, Tertiary, Human, Protein Binding
Protein Folding, Protein Structure, 570, Knockout, Inbred C57BL, Virus Replication, Research Support, Histone Deacetylase 6, Membrane Fusion, Microtubules, Histone Deacetylases, Cell Line, N.I.H., Gene Knockout Techniques, Mice, Capsid, Cell Line, Tumor, Influenza, Human, Journal Article, Animals, Humans, Non-U.S. Gov't, Cell Nucleus, Mice, Knockout, Myosin Type II, Tumor, Ubiquitin, Extramural, Dyneins, Dynactin Complex, Virus Internalization, Influenza, Mice, Inbred C57BL, Ribonucleoproteins, Influenza A virus, Host-Pathogen Interactions, RNA Interference, Microtubule-Associated Proteins, Tertiary, Human, Protein Binding
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