Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication
Copyright policy )Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication
How to stop after copying the genome Replication is highly regulated: Failure to copy any part of the genome or copying parts of it more than once can cause genome instability with potentially disastrous consequences. Maric et al. and Priego Moreno et al. show that the DNA replication machinery, which stably encircles DNA during the duplication process, is actively disassembled once replication is complete (see the Perspective by Bell). The protein ring encircling the DNA is covalently modified, which allows it to be opened and the whole replication complex to be removed from DNA by a special disassembly complex. Science , this issue 10.1126/science.1253596 , p. 477 ; see also p. 418
- University of Salford United Kingdom
- Medical Research Council United Kingdom
- University Of Warwick
- Dow Chemical (United Kingdom) United Kingdom
- University of Warwick Finland
Adenosine Triphosphatases, DNA Replication, 570, Saccharomyces cerevisiae Proteins, Minichromosome Maintenance Proteins, Ribonucleoprotein, U4-U6 Small Nuclear, QH, F-Box Proteins, Ubiquitin-Protein Ligases, Nuclear Proteins, Cell Cycle Proteins, Saccharomyces cerevisiae, QR, DNA-Binding Proteins, Valosin Containing Protein, 616, Ribonucleoprotein, U5 Small Nuclear
Adenosine Triphosphatases, DNA Replication, 570, Saccharomyces cerevisiae Proteins, Minichromosome Maintenance Proteins, Ribonucleoprotein, U4-U6 Small Nuclear, QH, F-Box Proteins, Ubiquitin-Protein Ligases, Nuclear Proteins, Cell Cycle Proteins, Saccharomyces cerevisiae, QR, DNA-Binding Proteins, Valosin Containing Protein, 616, Ribonucleoprotein, U5 Small Nuclear
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