Transcription-Independent Function of Polycomb Group Protein PSC in Cell Cycle Control
Copyright policy )Transcription-Independent Function of Polycomb Group Protein PSC in Cell Cycle Control
Silence, Please Polycomb group (PcG) proteins play pivotal roles in epigenetic gene control, development, and disease. PcG proteins can control cell cycle progression, but the underlying mechanisms remain unclear. PcG proteins are thought to silence transcription of target genes through modulating chromatin structure. Mohd-Sarip et al. (p. 744 , published online 5 April) uncovered an unanticipated transcription-independent function for the canonical PcG protein “Posterior sex combs” in cell cycle control, through its direct regulation of cyclin B destruction.
- Erasmus University Rotterdam Netherlands
- Queen's University Belfast United Kingdom
- Erasmus University Medical Center Netherlands
- University of British Columbia Canada
570, Proteasome Endopeptidase Complex, 610, Mitosis, Cyclin B, Anaphase-Promoting Complex-Cyclosome, Cell Line, name=General, SDG 3 - Good Health and Well-being, /dk/atira/pure/subjectarea/asjc/2700/2700, /dk/atira/pure/subjectarea/asjc/1000, EMC MGC-02-21-01, Animals, Drosophila Proteins, Protein Interaction Domains and Motifs, Compound Eye, Arthropod, Gene Silencing, name=General Medicine, Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome, Polycomb Repressive Complex 1, Cell Cycle Checkpoints, name=SDG 3 - Good Health and Well-being, DNA-Binding Proteins, G2 Phase Cell Cycle Checkpoints, Drosophila melanogaster, Phenotype, Imaginal Discs, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, Carrier Proteins, Protein Binding
570, Proteasome Endopeptidase Complex, 610, Mitosis, Cyclin B, Anaphase-Promoting Complex-Cyclosome, Cell Line, name=General, SDG 3 - Good Health and Well-being, /dk/atira/pure/subjectarea/asjc/2700/2700, /dk/atira/pure/subjectarea/asjc/1000, EMC MGC-02-21-01, Animals, Drosophila Proteins, Protein Interaction Domains and Motifs, Compound Eye, Arthropod, Gene Silencing, name=General Medicine, Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome, Polycomb Repressive Complex 1, Cell Cycle Checkpoints, name=SDG 3 - Good Health and Well-being, DNA-Binding Proteins, G2 Phase Cell Cycle Checkpoints, Drosophila melanogaster, Phenotype, Imaginal Discs, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, Carrier Proteins, Protein Binding
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