Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila
Copyright policy )Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila
Curing Insect Brain Tumors Mammalian tumors often show ectopic expression of genes that normally function only in the germ line. The possible contribution of cancer germline (CG) genes to malignancy is unknown. Janic et al. (p. 1824 ; see the Perspective by Wu and Ruvkun ) found that CG genes are also expressed in Drosophila brain tumors caused by mutants in the gene lethal (3) malignant brain tumor . Moreover, inactivation of some of these genes suppressed fly tumor growth. Because some Drosophila CG genes are orthologs of human CG genes, it is possible that inactivation of germline genes may show human tumor suppressor activity.
Brain Neoplasms, Gene Expression Profiling, Brain, Genes, Insect, DEAD-box RNA Helicases, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Disease Models, Animal, MicroRNAs, Cell Transformation, Neoplastic, Drosophila melanogaster, Germ Cells, Peptide Initiation Factors, Argonaute Proteins, Models, Animal, Animals, Drosophila Proteins, Humans, Genes, Tumor Suppressor, Neoplasm Transplantation
Brain Neoplasms, Gene Expression Profiling, Brain, Genes, Insect, DEAD-box RNA Helicases, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Disease Models, Animal, MicroRNAs, Cell Transformation, Neoplastic, Drosophila melanogaster, Germ Cells, Peptide Initiation Factors, Argonaute Proteins, Models, Animal, Animals, Drosophila Proteins, Humans, Genes, Tumor Suppressor, Neoplasm Transplantation
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