Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation
Copyright policy )Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation
Making Split Decisions Development of the vertebrate vasculature has been thought to involve just two mechanisms of blood vessel formation. Herbert et al. (p. 294 ; see the Perspective by Benedito and Adams ) identified a third mechanism in zebrafish in which two distinct, unconnected vessels can be derived from a single precursor vessel. Several vascular endothelial growth factors and signaling pathways, including ephrin and notch signaling, coordinated the sorting and segregation of a mixture of arterial and venous-fated precursor cells into distinct arterial and venous vessels. These findings provide a mechanistic framework for how mixed populations of cells can coordinate their behavior to segregate and form distinct blood vessels.
- University of California, San Francisco United States
- University of Leeds United Kingdom
- University of Salford United Kingdom
- Max Planck Society Germany
Vascular Endothelial Growth Factor A, Receptors, Notch/metabolism, Zebrafish Proteins/metabolism, Receptor, EphB4, Aorta/cytology/embryology, Genetically Modified, Ephrin-B2, Veins, Animals, Genetically Modified, Endothelial Cells/cytology/*physiology, Phosphatidylinositol 3-Kinases, Vascular Endothelial Growth Factor Receptor-2/metabolism, Cell Movement, Receptors, Arteries/cytology/*embryology, Morphogenesis, Notch/metabolism, Animals, Vascular Endothelial Growth Factor Receptor-3/metabolism, Aorta, Zebrafish, Stem Cells/cytology/*physiology, Receptors, Notch, Stem Cells, *Morphogenesis, EphB4/*metabolism, Vascular Endothelial Growth Factor A/metabolism, Endothelial Cells, Receptor, EphB4/*metabolism, Arteries, Zebrafish Proteins, Vascular Endothelial Growth Factor Receptor-3, Vascular Endothelial Growth Factor Receptor-2, Veins/cytology/*embryology, Phosphatidylinositol 3-Kinases/metabolism, Ephrin-B2/*metabolism, Receptor, Signal Transduction
Vascular Endothelial Growth Factor A, Receptors, Notch/metabolism, Zebrafish Proteins/metabolism, Receptor, EphB4, Aorta/cytology/embryology, Genetically Modified, Ephrin-B2, Veins, Animals, Genetically Modified, Endothelial Cells/cytology/*physiology, Phosphatidylinositol 3-Kinases, Vascular Endothelial Growth Factor Receptor-2/metabolism, Cell Movement, Receptors, Arteries/cytology/*embryology, Morphogenesis, Notch/metabolism, Animals, Vascular Endothelial Growth Factor Receptor-3/metabolism, Aorta, Zebrafish, Stem Cells/cytology/*physiology, Receptors, Notch, Stem Cells, *Morphogenesis, EphB4/*metabolism, Vascular Endothelial Growth Factor A/metabolism, Endothelial Cells, Receptor, EphB4/*metabolism, Arteries, Zebrafish Proteins, Vascular Endothelial Growth Factor Receptor-3, Vascular Endothelial Growth Factor Receptor-2, Veins/cytology/*embryology, Phosphatidylinositol 3-Kinases/metabolism, Ephrin-B2/*metabolism, Receptor, Signal Transduction
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