A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans
Copyright policy )A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans
The microRNA lin-4 and its target, the putative transcription factor lin-14 , control the timing of larval development in Caenorhabditis elegans . Here, we report that lin-4 and lin-14 also regulate life span in the adult. Reducing the activity of lin-4 shortened life span and accelerated tissue aging, whereas overexpressing lin-4 or reducing the activity of lin-14 extended life span. Lifespan extension conferred by a reduction in lin-14 was dependent on the DAF-16 and HSF-1 transcription factors, suggesting that the lin-4 – lin-14 pair affects life span through the insulin/insulin-like growth factor–1 pathway. This work reveals a role for microRNAs and developmental timing genes in life-span regulation.
- Yale University United States
Aging, Longevity, Molecular Sequence Data, Gene Expression Regulation, Developmental, Nuclear Proteins, Forkhead Transcription Factors, Receptor, Insulin, Lipofuscin, Repressor Proteins, MicroRNAs, Mutation, Animals, Insulin, Amino Acid Sequence, Genes, Developmental, Insulin-Like Growth Factor I, RNA, Helminth, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Heat-Shock Response
Aging, Longevity, Molecular Sequence Data, Gene Expression Regulation, Developmental, Nuclear Proteins, Forkhead Transcription Factors, Receptor, Insulin, Lipofuscin, Repressor Proteins, MicroRNAs, Mutation, Animals, Insulin, Amino Acid Sequence, Genes, Developmental, Insulin-Like Growth Factor I, RNA, Helminth, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Heat-Shock Response
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