The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma
Copyright policy )The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma
SummaryWe conducted a clinical trial to compare the molecular and cellular responses of human melanocytes and keratinocytes in vivo to solar‐simulated ultraviolet radiation (SSUVR) in 57 Caucasian participants grouped according to MC1R genotype. We found that, on average, the density of epidermal melanocytes 14 days after exposure to 2 minimal erythemal dose (MED) SSUVR was twofold higher than baseline (unirradiated) skin. However, the change in epidermal melanocyte counts among people carrying germline MC1R variants (97% increase) was significantly less than those with wild‐type MC1R (164% increase; P = 0.01). We also found that sunscreen applied to the skin before exposure to 2 MED SSUVR completely blocked the effects of DNA damage, p53 induction, and cellular proliferation in both melanocytes and keratinocytes.
- University of the Sunshine Coast Australia
- Queensland University of Technology Australia
- QIMR Berghofer Medical Research Institute Australia
- University of Queensland Australia
- University of Queensland Australia
Adult, Male, 1300 Biochemistry, Sun exposure, FoR 11 (Medical and Health Sciences), proliferation, Proliferation, 610, Fluorescent Antibody Technique, Genetics and Molecular Biology, Apoptosis, Cell Count, 2708 Dermatology, sun exposure, MC1R, melanoma, Humans, FoR 06 (Biological Sciences), Melanoma, Cell Proliferation, Sunbathing, Caspase 3, Genetic Variation, melanocytes, Phenotype, Erythema, Pyrimidine Dimers, Melanocytes, 2730 Oncology, Female, Tumor Suppressor Protein p53, Receptor, Melanocortin, Type 1, Sunscreening Agents, Sun Exposure, DNA Damage
Adult, Male, 1300 Biochemistry, Sun exposure, FoR 11 (Medical and Health Sciences), proliferation, Proliferation, 610, Fluorescent Antibody Technique, Genetics and Molecular Biology, Apoptosis, Cell Count, 2708 Dermatology, sun exposure, MC1R, melanoma, Humans, FoR 06 (Biological Sciences), Melanoma, Cell Proliferation, Sunbathing, Caspase 3, Genetic Variation, melanocytes, Phenotype, Erythema, Pyrimidine Dimers, Melanocytes, 2730 Oncology, Female, Tumor Suppressor Protein p53, Receptor, Melanocortin, Type 1, Sunscreening Agents, Sun Exposure, DNA Damage
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