Single nucleotide polymorphisms of 17β‐hydroxysteroid dehydrogenase type 7 gene: Mechanism of estramustine‐related adverse reactions?
Copyright policy )Single nucleotide polymorphisms of 17β‐hydroxysteroid dehydrogenase type 7 gene: Mechanism of estramustine‐related adverse reactions?
Objectives: To investigate the influence of single nucleotide polymorphisms (SNP) on transcription of the 17β‐hydroxysteroid dehydrogenase (HSD17B7) gene.Methods: Luciferase reporter genes containing a 5′‐flanking of the HSD17B7 gene, as well as the sequence around the SNP, were transfected into LNCaP and DU145 cells. Then, luciferase assays were carried out.Results: The presence of the G allele resulted in an increase of transcriptional activity derived from the 5′‐flanking region of the HSD17B7 gene by 270% and 370% in LNCaP and DU145 cells, respectively. Transcriptional activity of the HSD17B7 gene containing the G allele was higher than that of the C allele.Conclusions: The transcriptional activity of the HSD17B7 gene containing the G allele is higher than that of the C allele. This difference in HSD17B7 expression may regulate the risk of peripheral edema as an adverse reaction induced by estramustine phosphate sodium.
17-Hydroxysteroid Dehydrogenases, Antineoplastic Agents, Hormonal, Transcription, Genetic, Estramustine, Tumor Cells, Cultured, Edema, Humans, Polymorphism, Single Nucleotide
17-Hydroxysteroid Dehydrogenases, Antineoplastic Agents, Hormonal, Transcription, Genetic, Estramustine, Tumor Cells, Cultured, Edema, Humans, Polymorphism, Single Nucleotide
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