Characterizing Embryonic Gene Expression Patterns in the Mouse Using Nonredundant Sequence-Based Selection
Copyright policy )Characterizing Embryonic Gene Expression Patterns in the Mouse Using Nonredundant Sequence-Based Selection
This article investigates the expression patterns of 160 genes that are expressed during early mouse development. The cDNAs were isolated from 7.5 d postcoitum (dpc) endoderm, a region that comprises visceral endoderm (VE), definitive endoderm, and the node-tissues that are required for the initial steps of axial specification and tissue patterning in the mouse. To avoid examining the same gene more than once, and to exclude potentially ubiquitously expressed housekeeping genes, cDNA sequence was derived from 1978 clones of the Endoderm library. These yielded 1440 distinct cDNAs, of which 123 proved to be novel in the mouse. In situ hybridization analysis was carried out on 160 of the cDNAs, and of these, 29 (18%) proved to have restricted expression patterns.
- University of Copenhagen Denmark
- University of Queensland Australia
- University of Cambridge United Kingdom
- Medical Research Council United Kingdom
- UNSW Sydney Australia
570, 2716 Genetics (clinical), DNA, Complementary, Crosses, Inbred C57BL, Medical and Health Sciences, Mice, 1311 Genetics, Genetic, Complementary, Animals, Developmental, Crosses, Genetic, Gene Library, Gene Expression Profiling, Endoderm, Inbred CBA, Gene Expression Regulation, Developmental, DNA, Sequence Analysis, DNA, Biological Sciences, Mice, Inbred C57BL, Gene Expression Regulation, Mice, Inbred CBA, Sequence Analysis
570, 2716 Genetics (clinical), DNA, Complementary, Crosses, Inbred C57BL, Medical and Health Sciences, Mice, 1311 Genetics, Genetic, Complementary, Animals, Developmental, Crosses, Genetic, Gene Library, Gene Expression Profiling, Endoderm, Inbred CBA, Gene Expression Regulation, Developmental, DNA, Sequence Analysis, DNA, Biological Sciences, Mice, Inbred C57BL, Gene Expression Regulation, Mice, Inbred CBA, Sequence Analysis
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