Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
Copyright policy )Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
The superoxide radical (O2−) has long been considered a major cause of aging. O2− in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested the impact of each SOD isoform in Caenorhabditis elegans by manipulating its five sod genes and saw no major effects on life span. sod genes are not required for daf-2 insulin/IGF-1 receptor mutant longevity. However, loss of the extracellular Cu/ZnSOD sod-4 enhances daf-2 longevity and constitutive diapause, suggesting a signaling role for sod-4. Overall, these findings imply that O2− is not a major determinant of aging in C. elegans.
- University College London United Kingdom
- Ghent University Belgium
- UNIVERSITY COLLEGE LONDON, Bartlett School of Planning United Kingdom
- University of Ghent - Department of Biology
Aging, Superoxide Dismutase, Models, Biological, Receptor, Insulin, Isoenzymes, Oxidative Stress, Life Expectancy, Superoxides, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Gene Deletion
Aging, Superoxide Dismutase, Models, Biological, Receptor, Insulin, Isoenzymes, Oxidative Stress, Life Expectancy, Superoxides, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Gene Deletion
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