Initiating chromosome replication in E. coli: it makes sense to recycle
Copyright policy )Initiating chromosome replication in E. coli: it makes sense to recycle
Initiating new rounds of Escherichia coli chromosome replication requires DnaA-ATP to unwind the replication origin, oriC, and load DNA helicase. In this issue of Genes & Development, Fujimitsu and colleagues (pp. 1221–1233) demonstrate that two chromosomal sites, termed DARS (DnaA-reactivating sequences), recycle inactive DnaA-ADP into DnaA-ATP. Fujimitsu and colleagues propose these sites are necessary to attain the DnaA-ATP threshold during normal growth and are important regulators of initiation timing in bacteria.
- Florida Institute of Technology United States
DNA Replication, DNA-Binding Proteins, Nucleoproteins, Bacterial Proteins, Protein Biosynthesis, Cell Membrane, Escherichia coli, DNA, Intergenic, Chromosomes, Bacterial
DNA Replication, DNA-Binding Proteins, Nucleoproteins, Bacterial Proteins, Protein Biosynthesis, Cell Membrane, Escherichia coli, DNA, Intergenic, Chromosomes, Bacterial
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