Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis
Copyright policy )Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis
The Drosophila let-7-Complex (let-7-C) is a polycistronic locus encoding three ancient microRNAs: let-7, miR-100, and fly lin-4 (miR-125). We find that the let-7-C locus is principally expressed in the pupal and adult neuromusculature. let-7-C knockout flies appear normal externally but display defects in adult behaviors (e.g., flight, motility, and fertility) as well as clear juvenile features in their neuromusculature. We find that the function of let-7-C to ensure the appropriate remodeling of the abdominal neuromusculature during the larval-to-adult transition is carried out predominantly by let-7 alone. This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior.
- Howard Hughes Medical Institute United States
- University of California, San Francisco United States
- University of Massachusetts Medical School United States
- Dartmouth College United States
- University of California San Francisco United States
Male, Neuromuscular Junction, Genetically Modified, Biochemistry, Nervous System, Molecular Genetics, Animals, Genetically Modified, let-7-Complex, let-7, heterochronic developmental timing, Animals, Developmental, Transgenes, Molecular Biology, Life Cycle Stages, Metamorphosis, microRNA, Muscles, Metamorphosis, Biological, Gene Expression Regulation, Developmental, Biological, MicroRNAs, Gene Expression Regulation, Larva, Drosophila, Female, Developmental Biology
Male, Neuromuscular Junction, Genetically Modified, Biochemistry, Nervous System, Molecular Genetics, Animals, Genetically Modified, let-7-Complex, let-7, heterochronic developmental timing, Animals, Developmental, Transgenes, Molecular Biology, Life Cycle Stages, Metamorphosis, microRNA, Muscles, Metamorphosis, Biological, Gene Expression Regulation, Developmental, Biological, MicroRNAs, Gene Expression Regulation, Larva, Drosophila, Female, Developmental Biology
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).204 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!