phospholipase C gamma-1is required downstream ofvascular endothelial growth factorduring arterial development
Copyright policy )phospholipase C gamma-1is required downstream ofvascular endothelial growth factorduring arterial development
In this study, we utilize transgenic zebrafish with fluorescently labeled blood vessels to identify and characterize a mutant (y10) that displays specific defects in the formation of arteries, but not veins. We find thaty10encodesphospholipase C gamma-1(plcg1), a known effector of receptor tyrosine kinase signaling. We further show thatplcg1y10mutant embryos fail to respond to exogenous Vegf. Our results indicate that Plcg1 functions specifically downstream of the Vegf receptor during embryonic development to govern formation of the arterial system.
- National Institutes of Health United States
- National Institute of Health Pakistan
Male, Lymphokines, Embryo, Nonmammalian, Base Sequence, Phospholipase C gamma, Genetic Carrier Screening, Molecular Sequence Data, Gene Expression Regulation, Developmental, Arteries, Endothelial Growth Factors, Polymerase Chain Reaction, Muscle, Smooth, Vascular, Recombinant Proteins, Animals, Genetically Modified, Animals, Intercellular Signaling Peptides and Proteins, Female, RNA, Messenger, Crosses, Genetic, DNA Primers
Male, Lymphokines, Embryo, Nonmammalian, Base Sequence, Phospholipase C gamma, Genetic Carrier Screening, Molecular Sequence Data, Gene Expression Regulation, Developmental, Arteries, Endothelial Growth Factors, Polymerase Chain Reaction, Muscle, Smooth, Vascular, Recombinant Proteins, Animals, Genetically Modified, Animals, Intercellular Signaling Peptides and Proteins, Female, RNA, Messenger, Crosses, Genetic, DNA Primers
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