PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis
Copyright policy )PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis
PC3TIS21/BTG2 is member of a novel family of antiproliferative genes (BTG1, ANA/BTG3, PC3B, TOB, and TOB2) that play a role in cellular differentiation. We have previously shown that PC3TIS21/BTG2 is induced by nerve growth factor (NGF) at the onset of neuronal differentiation in the neural crest-derived PC12 cell line, and is a marker for neuronal birth. We now observe that PC3TIS21/BTG2 ectopically expressed in PC12 cells synergises with NGF, similarly to the cyclin-dependent kinase inhibitor p21, potentiating the induction of the neuronal markers tyrosine hydroxylase and neurofilament 160 kDa. Furthermore, PC3TIS21/BTG2 protects from apoptosis elicited by NGF deprivation in terminally differentiated PC12 cultures. Such effects might be a consequence of the arrest of cell cycle exerted by PC3TIS21/BTG2, or expression of a sensitizing (neurogenic) property of the molecule.
- University of Verona Italy
- National Research Council Italy
- Howard Hughes Medical Institute United States
Neurons, Tumor Suppressor Proteins, Apoptosis, Cell Differentiation, NGF; neuron; apoptosis, PC3/Tis21/Btg2; proliferation, PC12 Cells, Growth Inhibitors, Immediate-Early Proteins, Rats, Neuroprotective Agents, Neurofilament Proteins, Nerve Growth Factor, Animals, Genes, Immediate-Early
Neurons, Tumor Suppressor Proteins, Apoptosis, Cell Differentiation, NGF; neuron; apoptosis, PC3/Tis21/Btg2; proliferation, PC12 Cells, Growth Inhibitors, Immediate-Early Proteins, Rats, Neuroprotective Agents, Neurofilament Proteins, Nerve Growth Factor, Animals, Genes, Immediate-Early
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