Contribution of IL-1 to resistance to Streptococcus pneumoniae infection
Copyright policy )Contribution of IL-1 to resistance to Streptococcus pneumoniae infection
The role of IL-1 in susceptibility to Streptococcus pneumoniae infection was studied in mice deficient in genes of the IL-1 family [i.e. IL-1alpha-/-, IL-1beta-/-, IL-1alpha/beta-/- and IL-1R antagonist (IL-1Ra)-/- mice] following intra-nasal inoculation. Intra-nasal inoculation of S. pneumoniae of IL-1beta-/- and IL-1alpha/beta-/- mice displayed significantly lower survival rates and higher nasopharyngeal and lung bacterial load as compared with control, IL-1alpha-/- and IL-1Ra-/- mice. Treatment of IL-1beta-/- mice with rIL-1beta significantly improved their survival. A significant increase in blood neutrophils was found in control, IL-1alpha-/- and IL-1Ra-/- but not in IL-1beta-/- and IL-1alpha/beta-/- mice. Local infiltrates of neutrophils and relatively preserved organ architecture were observed in the lungs of IL-1alpha-/- and control mice. However, S. pneumoniae-infected IL-1beta-/-, IL-1alpha/beta-/- and IL-1Ra-/- mice demonstrated diffuse pneumonia and tissue damage. Altogether, all three isoforms contribute to protection against S. pneumoniae; our results point to differential role of IL-1alpha and IL-1beta in the pathogenesis and control of S. pneumoniae infection and suggest that IL-1beta has a major role in resistance to primary pneumococcal infection while the role of IL-1alpha is less important.
- Ben-Gurion University of the Negev Israel
- University of Tokyo Japan
- Ludwig-Maximilians-Universität München Germany
- Pathologisches Institut Germany
Mice, Knockout, Mice, Inbred BALB C, Interleukin-1beta, Receptors, Interleukin-1, Pneumonia, Pneumococcal, Interleukin 1 Receptor Antagonist Protein, Mice, Streptococcus pneumoniae, Interleukin-1alpha, Nasopharynx, Animals, Humans, Female, Lung
Mice, Knockout, Mice, Inbred BALB C, Interleukin-1beta, Receptors, Interleukin-1, Pneumonia, Pneumococcal, Interleukin 1 Receptor Antagonist Protein, Mice, Streptococcus pneumoniae, Interleukin-1alpha, Nasopharynx, Animals, Humans, Female, Lung
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).78 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!