The Role of Major Histocompatibility Complex Alleles in the Susceptibility of Brazilian Patients to Develop the Myogenic Type of Graves' Orbitopathy
Copyright policy )The Role of Major Histocompatibility Complex Alleles in the Susceptibility of Brazilian Patients to Develop the Myogenic Type of Graves' Orbitopathy
To assess the frequency of the genetic markers HLA-DRB1 and DQB1 in patients with Graves' orbitopathy (GO) with and without extraocular muscle involvement.The frequencies of class II HLA-DRB1 and DQB1 allele groups were determined for 81 Brazilian patients with GO and 161 normal subjects. The patients were divided into myogenic and nonmyogenic groups based on the clinical characteristics of the orbitopathy and quantitative computed tomography analysis of the extraocular muscle (EOM) dimensions.Compared to the frequency obtained for samples of normal subjects of the Brazilian population, HLA-DRB1 16 ( pc=0.008) was overrepresented in myogenic and HLA-DRB1 03 ( pc=0.02) in nonmyogenic patients.The association between the HLA-DRB1 16 and the myogenic subtype of GO suggests that EOM involvement in GO may be genetically predisposed.
- Universidade de São Paulo Brazil
- UNIVERSIDADE DE SAO PAULO Brazil
Adult, Male, HLA-DR Antigens, Middle Aged, Graves Disease, Major Histocompatibility Complex, Gene Frequency, Muscular Diseases, Case-Control Studies, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Female, Genetic Predisposition to Disease, Alleles, Brazil, HLA-DRB1 Chains
Adult, Male, HLA-DR Antigens, Middle Aged, Graves Disease, Major Histocompatibility Complex, Gene Frequency, Muscular Diseases, Case-Control Studies, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Female, Genetic Predisposition to Disease, Alleles, Brazil, HLA-DRB1 Chains
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).8 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!