Human Herpesvirus 8 in Brazilian Amerindians: A Hyperendemic Population with a New Subtype
Copyright policy )Human Herpesvirus 8 in Brazilian Amerindians: A Hyperendemic Population with a New Subtype
Human herpesvirus 8 (HHV-8) epidemiology in Brazilian Amerindians was studied. Use of an immunofluorescence (IFA) test for latent antibody demonstrated that the prevalence of HHV-8 in 781 Amerindians of diverse tribes (overall, 53% prevalence) was not related to language group or sex but rather increased gradually from 41% in children /=30 years of age. In IFA-positive subjects, HHV-8 DNA was detected in 3 (16%) of 19 mononuclear cell samples from peripheral blood and in 1 of 16 saliva samples. The sequences of conserved ORF22 and K6 genes were typical of HHV-8, but the variable K1 gene sequences were only 70%-75% identical to other known HHV-8 strains. Thus, a new HHV-8 subtype, E, is hyperendemic in Brazilian Amerindians, although Kaposi's sarcoma has not been reported. Transmission is probably oral rather than sexual. The limited genetic pool in isolated groups may permit more frequent transmission of a virus with a low prevalence in heterogeneous populations.
- National Institutes of Health United States
- Instituto Evandro Chagas Brazil
- Yale University United States
- National Institute of Health Pakistan
- Science Applications International Corporation (United States) United States
Adult, Male, Adolescent, Indians, South American, Molecular Sequence Data, Age Factors, Herpesviridae Infections, Middle Aged, Antibodies, Viral, Child, Preschool, Consensus Sequence, Herpesvirus 8, Human, Ethnicity, Humans, Female, Amino Acid Sequence, Child, Brazil, Phylogeny, Aged
Adult, Male, Adolescent, Indians, South American, Molecular Sequence Data, Age Factors, Herpesviridae Infections, Middle Aged, Antibodies, Viral, Child, Preschool, Consensus Sequence, Herpesvirus 8, Human, Ethnicity, Humans, Female, Amino Acid Sequence, Child, Brazil, Phylogeny, Aged
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