Photo-crosslinked poly(ethylene glycol)-b-poly(ϵ-caprolactone) nanoparticles for controllable paclitaxel release
Copyright policy )Photo-crosslinked poly(ethylene glycol)-b-poly(ϵ-caprolactone) nanoparticles for controllable paclitaxel release
Novel biodegradable core-crosslinked nanoparticles (CNPs) consisting of methoxy poly(ethylene glycol)-block-poly(ϵ-caprolactone-co-γ-cinnamoyloxy-ϵ-caprolactone) (mPEG-b-P(CL-co-CCL)) were prepared and evaluated for paclitaxel (PTX) delivery. mPEG113-b-P(CL65.2-co-CCL10.1) had a higher drug loading efficiency (95%) compared to mPEG113-b-PCL93.1 (43%). The stability of NPs has been largely improved and PTX release was significantly inhibited by crosslinking via UV irradiation at λ = 254 nm. MTT assays demonstrated that both blank non-crosslinked and crosslinked NPs showed low cytotoxicity to NCL-H460 cells while PTX-loaded non-crosslinked and crosslinked NPs exhibited obvious cytotoxicity against NCL-H460 cells, and the cytotoxicity was both dose-dependent and time-dependent. Furthermore, after 48 h incubation the cell viability of PTX-loaded crosslinked NPs was lower compared to that of PTX-loaded non-crosslinked NPs or free PTX. These properties indicated that CNPs prepared from mPEG-b-P(CL-co-CCL) have great potentials as carriers for drug delivery.
- Zhejiang Ocean University China (People's Republic of)
- Tianjin University China (People's Republic of)
- PEKING UNION MEDICAL COLLEGE China (People's Republic of)
- Chinese Academy of Medical Sciences & Peking Union Medical College China (People's Republic of)
- Tianjin University China (People's Republic of)
Drug Carriers, Paclitaxel, Ultraviolet Rays, Drug Storage, Polyesters, Photochemical Processes, Cell Line, Delayed-Action Preparations, Nanoparticles, Ethylene Glycols, Particle Size, Hydrophobic and Hydrophilic Interactions, Micelles
Drug Carriers, Paclitaxel, Ultraviolet Rays, Drug Storage, Polyesters, Photochemical Processes, Cell Line, Delayed-Action Preparations, Nanoparticles, Ethylene Glycols, Particle Size, Hydrophobic and Hydrophilic Interactions, Micelles
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