Cellular and Physiological Roles for Phospholipase D1 in Cancer
Copyright policy )Cellular and Physiological Roles for Phospholipase D1 in Cancer
Phospholipase D enzymes have long been proposed to play multiple cell biological roles in cancer. With the generation of phospholipase D1 (PLD1)-deficient mice and the development of small molecule PLD-specific inhibitors, in vivo roles for PLD1 in cancer are now being defined, both in the tumor cells and in the tumor environment. We review here tools now used to explore in vivo roles for PLD1 in cancer and summarize recent findings regarding functions in angiogenesis and metastasis.
- Stony Brook University United States
Mice, Neovascularization, Pathologic, Neoplasms, Phospholipase D, Tumor Microenvironment, Animals, Humans, Enzyme Inhibitors, Neoplasm Metastasis, Mice, Mutant Strains
Mice, Neovascularization, Pathologic, Neoplasms, Phospholipase D, Tumor Microenvironment, Animals, Humans, Enzyme Inhibitors, Neoplasm Metastasis, Mice, Mutant Strains
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).41 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!