Interaction of the K Channel β Subunit, Hyperkinetic, with eag Family Members
Copyright policy )Interaction of the K Channel β Subunit, Hyperkinetic, with eag Family Members
Assembly of K channel alpha subunits of the Shaker (Sh) family occurs in a subfamily specific manner. It has been suggested that subfamily specificity also applies in the association of beta subunits with Sh channels (Rhodes, K. J., Keilbaugh, S. A., Barrezueta, N. X., Lopez, K. L., and Trimmer, J. S. (1995) J. Neurosci. 15, 5360-5371; Sewing, S., Roeper, J. and Pongs, O. (1996) Neuron 16, 455-463; Yu, W., Xu, J., and Li, M. (1996) Neuron 16, 441-453). Here we show that the Drosophila beta subunit homologue Hyperkinetic (Hk) associates with members of the ether go-go (eag), as well as Sh, families. Anti-EAG antibody coprecipitates EAG and HK indicating a physical association between proteins. Heterologously expressed Hk dramatically increases the amplitudes of eag currents and also affects gating and modulation by progesterone. Through their ability to interact with a range of alpha subunits, the beta subunits of voltage-gated K channels are likely to have a much broader impact on the signaling properties of neurons and muscle fibers than previously suggested.
- University of Wisconsin System United States
- University of Wisconsin–Oshkosh United States
- University of Wisconsin–Madison United States
- Brandeis University United States
Bridged-Ring Compounds, Potassium Channels, Electric Conductivity, Thiones, Norbornanes, Precipitin Tests, Ether-A-Go-Go Potassium Channels, Recombinant Proteins, Electrophysiology, Mice, Thiocarbamates, Potassium, Animals, Drosophila Proteins, Humans, Insect Proteins, Drosophila, Ion Channel Gating, Progesterone, Protein Binding
Bridged-Ring Compounds, Potassium Channels, Electric Conductivity, Thiones, Norbornanes, Precipitin Tests, Ether-A-Go-Go Potassium Channels, Recombinant Proteins, Electrophysiology, Mice, Thiocarbamates, Potassium, Animals, Drosophila Proteins, Humans, Insect Proteins, Drosophila, Ion Channel Gating, Progesterone, Protein Binding
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