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Proceedings of the National Academy of Sciences
Article
Data sources: UnpayWall
Proceedings of the National Academy of Sciences
Article . 1989 . Peer-reviewed
Data sources: Crossref
Proceedings of the National Academy of Sciences
Article . 1989
Data sources: Europe PubMed Central
https://dx.doi.org/10.1073/pna...
Article
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Rat glucokinase gene: structure and regulation by insulin.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1989 English Publisher:Proceedings of the National Academy of SciencesJournal:Proceedings of the National Academy of Sciences, volume 86, pages 4,838-4,842 (issn: 0027-8424, eissn: 1091-6490, Copyright policy )
Authors: M A, Magnuson; T L, Andreone; R L, Printz; S, Koch; D K, Granner;

doi: 10.1073/pnas.86.13.4838

pmid: 2662183

pmc: PMC297510

Rat glucokinase gene: structure and regulation by insulin.

Abstract

The glucokinase gene is 15.5-kilobases long, appears to be present as a single copy, and contains 10 exons that range in size from 96 to 977 base pairs. The transcription start site was located 127 nucleotides upstream from the translation initiation codon. The 5' flanking DNA contains several regions similar to defined promoter elements. These include a probable "TATA box," an Sp1 binding site, and several elements related to liver-specific gene expression. In addition, we determined that transcription of the glucokinase gene increased at least 20-fold when diabetic rats were treated with insulin for 2 hr.

Related Organizations
Keywords

Cell Nucleus, Male, Base Sequence, Transcription, Genetic, Molecular Sequence Data, Restriction Mapping, Rats, Inbred Strains, Exons, Introns, Diabetes Mellitus, Experimental, Rats, Gene Expression Regulation, Genes, Liver, Glucokinase, Animals, Insulin

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 233
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
233
Top 10%
Top 1%
Top 1%
bronze