Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax
Copyright policy )Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax
tBid (truncated Bid/p15) and Bim activate Bax to permeabilize mitochondria and induce apoptosis. Binding of tBid and Bim to membranes is facilitated by electrostatic interactions. Additionally, cardiolipin (CL), like Mtch2, promotes the activating conformational change of tBid.
- McMaster University Canada
- University of Toronto Canada
- Sunnybrook Health Science Centre Canada
- Sunnybrook Research Institute Canada
Mice, Knockout, Bcl-2-Like Protein 11, Cardiolipins, Protein Conformation, Membrane Proteins, Apoptosis, Mitochondria, Liver, Models, Biological, Permeability, Membrane Lipids, Mice, Cholesterol, Proto-Oncogene Proteins, Liposomes, Mitochondrial Membranes, Mutagenesis, Site-Directed, Animals, Humans, Apoptosis Regulatory Proteins, BH3 Interacting Domain Death Agonist Protein
Mice, Knockout, Bcl-2-Like Protein 11, Cardiolipins, Protein Conformation, Membrane Proteins, Apoptosis, Mitochondria, Liver, Models, Biological, Permeability, Membrane Lipids, Mice, Cholesterol, Proto-Oncogene Proteins, Liposomes, Mitochondrial Membranes, Mutagenesis, Site-Directed, Animals, Humans, Apoptosis Regulatory Proteins, BH3 Interacting Domain Death Agonist Protein
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).56 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!