MN1 overexpression is an important step in the development of inv(16) AML
Copyright policy )MN1 overexpression is an important step in the development of inv(16) AML
The gene encoding the transcriptional co-activator MN1 is the target of the reciprocal chromosome translocation (12;22)(p13;q12) in some patients with acute myeloid leukemia (AML). In addition, expression array analysis showed that MN1 was overexpressed in AML specified by inv(16), in some AML overexpressing ecotropic viral integration 1 site (EVI1) and in some AML without karyotypic abnormalities. Here we describe that mice receiving transplants of bone marrow (BM) overexpressing MN1 rapidly developed myeloproliferative disease (MPD). This BM also generated myeloid cell lines in culture. By mimicking the situation in human inv(16) AML, forced coexpression of MN1 and Cbfbeta-SMMHC rapidly caused AML in mice. These findings identify MN1 as a highly effective hematopoietic oncogene and suggest that MN1 overexpression is an important cooperative event in human inv(16) AML.
- National Institute of Health Pakistan
- Erasmus University Rotterdam Netherlands
- St. Jude Children's Research Hospital United States
- National Human Genome Research Institute United States
Oncogene Proteins, Myeloproliferative Disorders, Oncogene Proteins, Fusion, Tumor Suppressor Proteins, Mice, Transgenic, EMC MM-03-24-01, Flow Cytometry, Translocation, Genetic, Gene Expression Regulation, Neoplastic, Survival Rate, Mice, Leukemia, Myeloid, Acute Disease, Chromosome Inversion, Trans-Activators, Animals, Humans, Female, Cells, Cultured, Chromosomes, Human, Pair 16, Bone Marrow Transplantation
Oncogene Proteins, Myeloproliferative Disorders, Oncogene Proteins, Fusion, Tumor Suppressor Proteins, Mice, Transgenic, EMC MM-03-24-01, Flow Cytometry, Translocation, Genetic, Gene Expression Regulation, Neoplastic, Survival Rate, Mice, Leukemia, Myeloid, Acute Disease, Chromosome Inversion, Trans-Activators, Animals, Humans, Female, Cells, Cultured, Chromosomes, Human, Pair 16, Bone Marrow Transplantation
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